Tivozanib Capsules

Tivoxen 1.34mg Generic Tivozanib. Tivoxen capsule: Each capsule contains 1.34mgof Tivozanib equivalent to 1.5 mg of tivozanib hydrochloride INN. PHARMACOLOGY Mechanism of Action: Tivozanib is a tyrosine kinase inhibitor In vitro cellular kinase assays demonstrated that Tivozanib inhibits phosphorylation of vascular endothelial growth factor receptor(VEGFR)-1VEGFR-2 and VEGFR-3 and inhibits other kinases including C-kit and PDGFR at clinically relevant concentrations. In tumor xenograft models in mice and rats Tivozanib inhibited angiogenesis vascular permeability, and tumor growth of various tumor cell types including human renal cell carcinoma.

INDICATIONS:
Tivozanib is indicated for the treatment of adult patients with relapsed or refractory advanced renal cell carcinoma (RCC)following two or more prior systemic therapies.

DOSAGE AND ADMINISTRATION:
Recommended Dosing
The recommended dosage of Tivozanib is 1.34 mg taken orally once daily for 21 days on treatment followed by7 days off treatment for a 28-day cycle.
Continue treatment until disease progression or until unacceptable toxicity occurs
Take Tivozanib with or without food. Swallow the Tivozanib capsule whole with a glass of water Do not open the capsule
If a dose is missed the next dose should be taken at the next scheduled time. Do not take two doses at the same time.